Savchuk I.A. 1
Demidova M.A. 1
Petrova M.B. 1
1 Tver state medical academy
One perspective direction is the creation of iodine-containing drugs based on large marine brown alga Laminaria Japanese (Laminaria japonica Aresch). In experiments on mice (n = 30) there was held estimation of morphological changes in thyroid gland structure under the influence of Laminaria Japanese extract (45 mg/kg and 750 mg/kg). It was noted that the daily intragastric administration of Laminaria Japanese extract in doses of 45 mg/kg and 750 mg/kg on experimental animals led to noticeable changes in the thyroid gland structure. The changes can be characterized by increase in the area of large follicles in 1,6 times, average follicles in 1,6 and 1,5 times, respectively. In experiments on rabbits (n=12) there was made assessment of influence of dry Laminaria Japanese extract on thyroid gland function. It was stated, that intragastric administration of Laminaria extract (750 mg/kg) led to an increase of total tetraiodothyronine level in 1,3 times, and tetraiodothyronine total and free in 1,5 and 1,3 times respectively.