Scientific journal
Balanced diet, nutritional supplements and biostimulants
ISSN 2414-1054
ISSN 2414-1054
DEVELOPMENT AND STUDY OF PROBIOTIC CAPSULE DOSAGE FORM «IMBIСAPS»
Neschislyaev V.A. 1
Stolbova M.G. 1
Mokin P.A. 1
1 Perm branch «BIOMED» of MICROGEN State Unitary Company
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The purpose of this research was to develop of probiotic capsule dosage form with immobilized bifidobacteria. The strain of probiotic microorganism was Bifidobacterium bifidum 1. The possibility of brown algae homogenate application as a sorbent for probiotic microorganisms was studied. Variants of bifidobacteria immobilization were tested, and their resistance to gastric juice and bile was investigated. The work revealed high protective properties of the sorbent on the basis of brown algae and their homogenate was demonstrated as a promising sorbent for the production of probiotic preparations on the basis of the immobilized cells. Capsulate dosage form for probiotic with immobilized bifidobacteria was developed, along with the determination of the drug optimal composition, capsule size and type of packaging. The experimental samples of the probiotic retained the required level of the main quality attributes during 21 months.