Demidova M.A. 1
Savchuk I.A. 1
Shneur S.I. 1
1 Tver state medical academy
One perspective direction is the creation of laxatives on the basis of large marine brown sea grass Laminaria Japanese (Laminaria japonica Aresch.). In experiments on mice (n = 40) there was held comparative estimation of laxative activity of the extract of Laminaria Japanese dry (750mg/kg) with the effect of infusion of Laminaria thalli and laxatives (bisakodyl, forlax). There was noted the increase in the total amount of stool on average in 1.4 times, and softening of its consistency when using intragastric administration of the Laminaria extract on mice. It was established that the laxative activity of the Laminaria extract dry was on average 1.3 times weaker than that of bisacodyl (1 mg/kg), but it complied with the action of forlax (1 g/kg) and exceeded the activity of thalli laminaria infusion in 1.5 times on average.