Kryzhanovsky S.P. 1
Bogdanovich L.N. 1
Besednova N.N. 2
Ivanushko L.A. 2
Golovacheva V.D. 1
1 Federal State Budget Institution of Health Medical Assotiation
2 G.P. SOMOV Research Institute of Epidemiology and Microbiology
The purpose of this paper is to estimate the action of seaweed polysaccharides (composed of biologically active additive - Fukolam BAA) on lipid metabolism and level of inflammation markers in the blood of patients with dyslipidemia. In the composition of Fukolam BAA includes sulfated polysaccharide fucoidan and alginate from the brown alga Fucus evanescens. The polysaccharides used as support means for the basic therapy of patients with dislipidemia, as well as in combination with atorvastatin at doses of 20 and 10 mg per day. The long (over 6 months) therapy in patients with inclusion of polysaccharides helped the normalizetion of total cholesterol (TC), low density lipoprotein (LDL) cholesterol, atherogenic factor (AF), ratio АроВ/ApoA1, reduced levels of fibrinogen, C-reactive protein and proinflammatory cytokines. The possibility of lowering the dose of the statin in case of its combination with Fukolam, which may reduce the danger of side effects of the drug and reduce the cost of treatment. Furthermore, Fukolam can be used in cases contraindications to long-term use of statins in period of ambulatory observation of patients with a view to correction of lipid metabolism and reducing the intensity of chronic systemic inflammation.