Scientific journal
Balanced diet, nutritional supplements and biostimulants
ISSN 2414-1054
ISSN 2414-1054
CHANGES IN THE RELATIVE COPY NUMBER OF OCT4 AND SOX2 GENES IN MALIGNANCY OF GASTRIC TISSUE
Kit O.I.,Vodolazhsky D.I. 1
Gevorkyan Y.A. 1
Kutilin D.S. 1
Maleyko M.L. 1
Dvadnenko K.V. 1
Enin Y.S. 1
Gudueva EN. 1
1
1 Federal State Institution»Rostov Research Institute of Oncology» of the Ministry of Health of the Russian Federation
245 KB
Octamer-4 (OCT4) and the transcription factor SOX2 are involved in the regulation of human embryonic stem cells and may therefore play an important role in the progression of tumors. Since little is known about the effectiveness of OCT4 and SOX2 as potential biomarkers in the progression of gastric cancer, the variation of the degree of the relative copy number of these two genes was investigated by RT-qPCR in different histological types of gastric cancer tissues (adenocarcinoma G1-2, adenocarcinoma G3, adenocarcinoma G3 in combination with signet-ring cell stomach cancer and signet-ring cell cancer solely) compared with the adjacent healthy tissues.The significant decrease in the degree of relative copy number of genes OCT4 and SOX2was foundin the tissues of gastric cancer of histological types of adenocarcinoma G1-2 and adenocarcinoma G3. For other histological types of gastric cancer (adenocarcinoma G3 combined with signet-ring cell cancer and signet-ring cell cancersolely) significant changes in the relative copy number of genes OCT4 and SOX2 were not detected.