Yakusheva E.N. 1
Sychev I.A. 1
Kirichenko E.E. 1
Schulkin A.V. 1
1 RyazanStateMedicalUniversity.a. I.P. Pavlov
We have isolated the polysaccharide complex from the flowers of tansy. We investigated the anti-inflammatory and antioxidant activity of selected polysaccharide on the model exudative inflammation caused by the introduction of formalin solution of the hind legs of the rat. Polysaccharide reduces tissue swelling swollen limbs, reduces the number of white blood cells, normalizes the ESR. Anti-inflammatory activity of polysaccharide comparable with diclofenac-sodium. Polysaccharide complex manifests expressed an antioxidant effect, reduces the concentration of MDA, increases the content of protein-free thiol groups and activity of glutathione peroxidase. Study drug in the joint appointment with diclofenac-sodium fixes his Pro-oxidant action. We explored gastroprotective activity of polysaccharide for preventive reception on the model of indomethacin lesions of the gastric mucosa. Introduction of polysaccharide prevents various ulcers. On antiulcer activity of the drug is superior to ranitidine and compare with omeprazole.