Kim M.E. 1
Murzagulova K.B. 1
1 Pharmaceutical company «Romat»
Pharmaceutical company «ROMAT», Kazakhstan developed dispersible tablets RIZEF-D rifampicin/izonizid 60/30 mg, based on molecular encapsulated active substances with β-cyclodextrin to expand the range of specialized TB medicines for children. The bioavailability of developed drug production LLP «Pavlodar Pharmaceutical Plant» in comparison with the drug rifampicin tablets 60/izoniazid 30 production MacLeods Pharmaceuticals Ltd, India was studied to assess the bioequivalence of original drugs. The study was conducted on male rabbits Chinchilla. The concentration of drug in the blood serum was determined by HPLC. Pharmacokinetic rifampicin data showed a substance determination for 12 hours after a single administration to animals of the test and comparing drug. Time The time of onset of maximum concentration averaged 2 hours. The average maximum concentration of rifampicin in the test serum and the drug comparisons was 5,7 μg/ml. Rifampicin is slowly excreted from the organism, and 12 hours after drug administration still found in the plasma of the rabbits – 1,11 μg/ml. The relative bioavailability of rifampicin an average of 100,3 ± 6,04 %. Thus, the test and the reference rifampicin drugs demonstrated comparable pharmacokinetic characteristics.